ParaFishControl article on the role of BAFF / APRIL axis during proliferative kidney disease

Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease. PLoS ONE 12(3): e0174249. doi:10.1371/journal.pone.0174249

Proliferative kidney disease (PKD) is a parasitic infection of salmonid fish characterized by hyper-secretion of immunoglobulins in response to the presence of the myxozoan parasite, Tetracapsuloides bryosalmonae. In this context, we hypothesized that the BAFF/APRIL axis, known to play a major role in B cell differentiation and survival in mammals, could be affected by the parasite and consequently be involved in the apparent shift in normal B cell activity. The results presented in this paper support the premise that the BAFF / APRIL axis plays an important role during PKD, which may open the possibility of new therapeutic treatments against the disease.

University of Copenhagen Kurt Buchmann Mature parasite free rainbow trout
Rainbow trout © Kurt Buchmann, University of Copenhagen, Denmark

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